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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL5
All Species:
1.52
Human Site:
T677
Identified Species:
4.17
UniProt:
O76039
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76039
NP_001032420.1
1030
115538
T677
E
G
T
S
S
F
H
T
R
Q
K
S
E
G
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
NP_001129485
570
64691
E242
F
A
G
V
R
L
P
E
I
K
E
R
E
P
L
Dog
Lupus familis
XP_548881
960
107395
S628
R
A
K
G
L
D
G
S
L
S
V
G
Q
G
M
Cat
Felis silvestris
Mouse
Mus musculus
Q3UTQ8
938
105471
R610
S
S
Q
Q
R
P
H
R
H
S
M
Y
V
T
R
Rat
Rattus norvegicus
Q5XIT0
507
57117
Y179
L
L
V
G
D
V
K
Y
G
K
A
V
D
I
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514328
967
107039
G628
R
D
K
V
R
A
K
G
S
E
G
G
L
S
V
Chicken
Gallus gallus
XP_425571
960
107495
L629
S
K
G
S
E
G
G
L
S
V
G
Q
G
M
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001124243
1039
116666
P701
L
S
R
N
D
Q
S
P
K
E
K
P
H
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796071
627
72401
I299
L
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
26.7
88.1
N.A.
85.9
23.6
N.A.
76.5
75.2
N.A.
55.3
N.A.
N.A.
N.A.
N.A.
25.5
Protein Similarity:
100
N.A.
39.5
89.7
N.A.
88.9
36.5
N.A.
82.5
83.6
N.A.
69.1
N.A.
N.A.
N.A.
N.A.
39
P-Site Identity:
100
N.A.
6.6
6.6
N.A.
6.6
0
N.A.
0
6.6
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
N.A.
20
20
N.A.
6.6
13.3
N.A.
6.6
6.6
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
23
0
0
0
12
0
0
0
12
12
0
0
0
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% C
% Asp:
0
12
0
0
23
12
0
0
0
0
0
0
12
0
0
% D
% Glu:
12
0
0
0
12
0
0
12
0
23
12
0
23
0
0
% E
% Phe:
12
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
12
23
23
0
12
23
12
12
0
23
23
12
23
12
% G
% His:
0
0
0
0
0
0
23
0
12
0
0
12
12
0
12
% H
% Ile:
0
0
0
12
0
0
0
12
12
0
12
0
0
12
0
% I
% Lys:
0
12
23
0
0
0
23
0
23
23
23
0
0
0
0
% K
% Leu:
34
12
0
0
12
12
12
12
12
0
0
0
12
0
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
12
0
0
12
12
% M
% Asn:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
12
12
12
0
0
0
12
0
12
0
% P
% Gln:
0
0
12
12
0
23
0
0
0
12
0
12
12
0
0
% Q
% Arg:
23
0
12
0
34
0
0
12
12
0
0
12
0
0
23
% R
% Ser:
23
34
0
23
12
0
12
12
23
23
0
12
0
23
0
% S
% Thr:
0
0
12
0
0
0
0
12
0
0
0
0
0
12
0
% T
% Val:
0
0
12
23
0
12
0
0
0
12
12
12
12
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
12
% W
% Tyr:
0
0
12
0
12
0
0
12
0
0
0
12
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _